Official website · USA authorized SynoCell retailer
SynoCell is a dietary supplement capsule for joint comfort and mobility, made for adults.
Use case: daily joint support at 2 capsules a day with a meal, so one 60-capsule bottle lasts 30 days, with free standard shipping in the mainland U.S.
How it works: each serving combines ASU 310 mg, quercetin 310 mg, Boswellia extract 200 mg and hyaluronic acid 180 mg, with 5 mg of black pepper extract to help absorption.
Written by the SynoCell editorial team · Updated
How it works in 3 steps
One SynoCell serving is 2 capsules. It combines ASU 310 mg, quercetin 310 mg, Boswellia 200 mg, hyaluronic acid 180 mg and black pepper extract 5 mg. One 60-capsule bottle holds 30 servings.
Take SynoCell with a meal and a glass of water. Breakfast is easy to remember, and a meal helps the fat-soluble ASU absorb. Ask your pharmacist first if you take daily medicines.
One bottle of SynoCell lasts 30 days at 2 capsules a day. The 90-day money-back policy gives you three months to judge stairs, rising and walks, so you can decide after a fair trial.
The short version
SynoCell is a dietary supplement capsule used for joint comfort, mobility and flexibility. It is for adults, taken as 2 capsules a day. Each serving has five ingredients, and the brand prints the amount of every one.
SynoCell is a capsule supplement sold for joint comfort, mobility and flexibility. Each 2-capsule serving combines five ingredients, and the brand prints the amount of every one.
Two of them, avocado/soybean unsaponifiables (ASU) and hyaluronic acid, are close to the doses used in small trials. Boswellia is a resin extract with positive small trials, though of different extracts. Quercetin has no human arthritis trials, and black pepper extract is there to help absorption (Cameron and Chrubasik, 2014) (Tashiro et al., 2012) (Yu et al., 2020) (MSKCC, Quercetin). It is a dietary supplement, not a drug and not an arthritis treatment.
| What it is | Joint-support dietary supplement, 60 capsules per bottle |
|---|---|
| How to take it | 2 capsules a day (one serving); a meal and water make it easy to remember |
| Per serving | ASU 310 mg, quercetin 310 mg, Boswellia 200 mg, hyaluronic acid 180 mg, BioPerine 5 mg |
| Price | $59, $49 or $39 a bottle, by pack size |
| Shipping | Free standard shipping in the mainland U.S. |
| Money-back policy | 90 days; call +1 (302) 200-3480 with your order ID |
| Who sells it here | Synocell, USA authorized retailer (not the manufacturer) |
Read the full Supplement Facts, the five ingredients or the medicine interactions.
Step by step
Take 2 SynoCell capsules once a day with a meal and a glass of water, at the same time each day. Follow the directions on your bottle. The four steps below show how.
Swallow the serving on the label, 2 capsules, with a full glass of water.
Breakfast is easy to remember. A meal also helps the fat-soluble ASU absorb.
Keep the bottle by your coffee or toothbrush so you never double up.
Note stairs, rising from a chair and walks. Decide well before the 90-day window closes.
The formula
SynoCell has five ingredients: avocado/soybean unsaponifiables 310 mg, quercetin 310 mg, Boswellia serrata extract 200 mg, hyaluronic acid 180 mg and black pepper extract 5 mg. Open a card for the research dose and the main caution.
Persea americana and Glycine max oil fractions
Per serving: 310 mg
Small benefit300 mg a day (trials up to 3 years)
Watch forMade from soy and avocado: people with soy allergy should ask a clinician first.
Full profilePlant flavonoid
Per serving: 310 mg
No human joint trialsUp to 1,000 mg a day in general studies; no human arthritis trials
Watch forCan interact with several drugs, including warfarin, cyclosporine and some antibiotics.
Full profileBoswellia serrata (Indian frankincense)
Per serving: 200 mg
Small trials, positive100-250 mg a day of different extracts (5-Loxin, Aflapin)
Watch forUsually well tolerated; ask a doctor first if you take blood thinners.
Full profileSodium hyaluronate (a natural joint-fluid sugar)
Per serving: 180 mg
Small trials, mixed48-240 mg a day in small oral studies
Watch forSwallowed HA is not the same as HA joint injections; studies are small.
Full profilePiper nigrum fruit, standardized for piperine
Per serving: 5 mg
Absorption aid, not a joint ingredient5-30 mg a day in supplements; 15-20 mg in drug-interaction studies
Watch forPiperine can raise blood levels of some medicines. Tell your doctor or pharmacist.
Full profileNo proprietary blend: each amount is printed on the brand's Supplement Facts. See all five compared side by side.
Try SynoCell with a 90-day window2 capsules a day · from $39 a bottle · free standard U.S. shipping
Order nowRead the label
The SynoCell Supplement Facts panel gives one serving as 2 capsules, so a 60-capsule bottle holds 30 servings. It prints the amount of each of the five ingredients. Tap any line to see what it means for you.
Supplement Facts
Serving size 2 capsules · Servings per container 30
One serving is two capsules. The bottle holds 60, so it lasts 30 days.
Thirty days at one serving a day.
Close to the 300 mg used in trials; small pain benefit in reviews.
A plant flavonoid. No human osteoarthritis trials; can interact with some drugs.
Resin extract. Trials used other extracts at 100-250 mg.
Near the 200 mg used in a 12-month oral trial. Not the same as an injection.
Piperine helps absorption and can raise levels of some medicines.
There is no official daily amount for any of these five ingredients.
Typed from the brand store's Supplement Facts (SynoCell, product page). Check the panel on your bottle.
Tap a line of the panel to see what it means. The brand graphic pictures all five ingredients.
Dose check
For two ingredients, yes. ASU at 310 mg is close to the 300 mg used in trials, and hyaluronic acid is also near trial doses. The bars are drawn to scale against the amounts used in studies.
Many joint products hide small amounts inside a blend. SynoCell prints each one, and ASU and hyaluronic acid land near trial doses. That is a real point in its favor. It still does not prove the combination works: the trial benefits were small, and the Boswellia extract differs from the studied ones. Read every claim, checked.
Your day
Take SynoCell once a day at a time you will remember. Breakfast works for most people, and a meal helps the fat-soluble ASU absorb. Use the same time each day so it becomes a habit.
Take 2 capsules with food and water. ASU is fat-soluble, so a meal helps.
Evening is fine too. Pick one time and keep it, so you never take a second serving by mistake.
Exercise is the most strongly recommended step for joint pain. A short walk counts.
If you take prescriptions, ask your pharmacist about spacing them from the black pepper extract.
The brand lists 2 capsules as one serving; the times are examples. Exercise (ACR, 2026 OA guideline summary); piperine and medicines (Horn and Hansten, 2017).
Claims, checked
No trial has tested SynoCell itself. ASU showed a small pain benefit at a similar dose, different Boswellia extracts showed small benefits, and quercetin has no human joint trials. Each seller claim sits beside the research below.
The seller says
What the evidence shows
ASU and Boswellia showed small pain benefits in trials at similar doses; nobody has tested the SynoCell blend itself. (Cameron and Chrubasik, 2014) (Yu et al., 2020)
Some supportThe seller says
What the evidence shows
Boswellia trials reported better function scores over about 90 days; oral HA results were mixed. (Yu et al., 2020) (Guadagna et al., 2018)
Small trials onlyThe seller says
What the evidence shows
No human trial of these ingredients measured a “cytokine storm” in arthritis. Quercetin's joint data are animal and lab only. (MSKCC, Quercetin)
Not shownThe seller says
What the evidence shows
In a 3-year hip trial, ASU did not change average joint-space loss versus placebo. No supplement is shown to rebuild cartilage. (Maheu et al., 2014 (ERADIAS))
Not shownClaims are quoted from the bottle and the brand store; they are the seller's words, not ours.
It does not treat arthritis, rebuild cartilage or replace your doctor's plan. A joint that turns suddenly hot, red and swollen, or joint pain with fever, needs urgent care (MedlinePlus, Septic arthritis).
More on the benefits page and in the results timeline.
Where it fits
Exercise and weight loss are the best-proven steps for joint pain, according to the 2026 American College of Rheumatology guideline. A supplement like SynoCell is an add-on, not the first step.
Strongly recommended by the American College of Rheumatology for knee, hip and hand osteoarthritis. (ACR, 2026 OA guideline summary) (Kolasinski et al., 2020 (ACR/AF 2019 guideline))
Each pound lost takes about four pounds of load off the knee; strongly recommended for knee and hip OA. (Messier et al., 2005) (ACR, 2026 OA guideline summary)
Strongly recommended, with heart, stomach and kidney risks to discuss with a doctor. (ACR, 2026 OA guideline summary) (FDA, 2015 NSAID safety communication)
Four trials: pain about 8.5 points lower on a 0-100 scale, a benefit of questionable importance. (Cameron and Chrubasik, 2014)
Seven small trials, 545 patients, mostly positive; different extracts from SynoCell's. (Yu et al., 2020)
Small studies; one 12-month trial helped only people aged 70 or younger. (Tashiro et al., 2012) (Guadagna et al., 2018)
The 2026 ACR guideline strongly recommends against them for knee, hip and hand OA. (ACR, 2026 OA guideline summary)
Only animal and lab data for osteoarthritis. (MSKCC, Quercetin)
Bar length shows how much published evidence supports each option for osteoarthritis pain and function, based on the guideline and reviews linked here. A reading aid, not a score from any one source.
Exercise and, if you carry extra weight, weight loss have the strongest evidence. Each pound lost takes about four pounds of load off the knee (Messier et al., 2005). If you want to try SynoCell, add it to that plan, not instead of it. Read our knee pain guide.
Our honest take
SynoCell prints every ingredient amount, and ASU and hyaluronic acid sit near trial doses. The cons are that no trial has tested the formula itself, quercetin has no human joint trials, and some medicines may interact.
Quick check
SynoCell is for adults 18 and older. If you are pregnant or breastfeeding, skip it unless your doctor says otherwise. Ask first if you take blood thinners, cyclosporine, seizure or heart medicines, or have kidney disease or a soy allergy.
A checklist, not medical advice. Read who SynoCell is for and the interactions table.
Prices
On October 11, 2026 the brand store listed SynoCell at $59 for 1 bottle, $147 for 3 bottles ($49 each) and $234 for 6 bottles ($39 each). Standard shipping in the mainland U.S. is free.
Try it
$59per bottle
$59 total · about $1.97 a day
Free standard U.S. shipping
Most bought
$49per bottle
$147 total · about $1.63 a day
Free standard U.S. shipping
Lowest per bottle
$39per bottle
$234 total · about $1.30 a day
Free standard U.S. shipping
Prices as listed on the SynoCell brand store on October 11, 2026. Standard shipping is free in the mainland U.S.; Hawaii, Alaska and international orders pay a surcharge. The secure order page shows the final total and tax before you pay. No struck-through "was" prices are shown here, because we cannot verify that anyone ever paid them.
For 90 days you need 3 bottles. Lowest total: 3-bottle order for $147.
Uses the brand-store prices above, with free standard shipping in the mainland U.S. A planning aid only; the order page has the final total.
90-day window
SynoCell has a 90-day money-back policy. Call +1 (302) 200-3480 with your order ID. On the brand store, multi-pack refunds cover unopened bottles plus one opened bottle, minus about 10% shipping and handling.
Your order ID is the key to every refund call. Save the confirmation email and the box.
The brand lists 5-10 business days for standard U.S. delivery.
Boswellia trials ran about 90 days; a review suggests at least 4 weeks. Note stairs, rising and walks.
Not helping? Call the order desk now, while there is time to get a return label and ship the bottles.
Call +1 (302) 200-3480 before day 90. Multi-pack refunds cover unopened bottles plus one opened bottle.
Terms summarized from the brand's refund policy (SynoCell, shipping and refund policy). The brand deducts about 10% for shipping and handling on returns. Ask the order desk which rules apply to your order before you mail anything.
Return mail for orders placed here goes to 3 Times Square, Floor 12, New York, NY 10036, USA, with your full name, email and order ID. Full details on the guarantee page.
Reviews
SynoCell reviews appear here only after the order desk matches them to a real order, so no buyer reviews are shown yet. The empty slots below wait for real customers.
4.6out of 5
Based on 803 verified ratings
Filled in only from reviews the order desk has matched to a real order. How we check reviews.
I sit with crossword coffee. Stairs to the laundry. That's my scorecard. Week one: nothing. Week four: less of a hold on the rail. I keep it on the sewing table. I take it before I sweep the shop.
Pack review 1, as supplied
I do PT homework on the floor. Garden kneeling. I still use the pad. Capsules are extra, not a new knee. I keep it next to the PT bands. I take it after I set the crossword down.
Pack review 2, as supplied
I watch grandkids twice a week. Wanted the 30-second pitch. Didn't get it. Desk confirmed the window. Kept the 3-pack. I keep it in the ferry bag. I take it after I start the mixer.
Pack review 3, as supplied
Safety first
The brand does not publish side-effect data for SynoCell itself. The main concern is medicine interactions, because quercetin and black pepper extract can change how some drugs work. Ask your doctor or pharmacist first.
For most healthy adults, the ingredients were well tolerated in studies. The main questions are drug interactions, because quercetin and black pepper extract can change how some medicines are processed (MSKCC, Quercetin) (Horn and Hansten, 2017).
| If you take | Ingredient to ask about | Why |
|---|---|---|
| Blood thinners (warfarin and others) | Quercetin, Boswellia | A raised INR was reported with quercetin; Boswellia may add to bleeding risk. (MSKCC, Quercetin) (MSKCC, Boswellia) |
| Cyclosporine, some antibiotics (quinolones) | Quercetin | Listed moderate interactions. (RxList, Quercetin) |
| Seizure drugs (phenytoin, carbamazepine) | Black pepper extract | Piperine raised blood levels in small studies. (Horn and Hansten, 2017) (Ziegenhagen et al., 2021) |
| Heart and blood pressure drugs (propranolol, losartan) | Black pepper, quercetin | Piperine raised propranolol levels; quercetin may interact with losartan. (Ziegenhagen et al., 2021) (MSKCC, Quercetin) |
| Drugs cleared by liver CYP3A4 or CYP2C19 | Quercetin, black pepper | Both can slow how some drugs are broken down. (MSKCC, Quercetin) (Horn and Hansten, 2017) |
| NSAID pain relievers | None known | No listed interaction, but tell your doctor about every supplement you take. (NIH ODS, Dietary Supplements: What You Need to Know) |
SynoCell is sold as a dietary supplement and is not a drug. Ask your doctor or pharmacist first if you take blood thinners (such as warfarin), cyclosporine, seizure medicines, heart or blood pressure drugs, or any daily prescription, if you have kidney disease or a soy allergy, or if you are pregnant or nursing: quercetin and black pepper extract can change how some drugs work. See side effects and interactions.
If you think SynoCell caused a reaction, stop taking it and report it through FDA's Safety Reporting Portal (FDA, How to Report a Problem with Dietary Supplements).
From the blog
These articles cover the 2026 joint guideline and the ingredients in SynoCell in plain words. Read them to see what the research says before you decide whether to buy.
Tai chi moves to conditional, glucosamine stays out, fish oil and vitamin D join the no list. What it means for buyers.
Read the articleWhy movement and weight loss lead every knee arthritis guideline, with a simple plan to start.
Read the articleHow the black pepper extract in SynoCell can change medicine levels, which drugs were studied, and what to ask.
Read the articleFAQ
Short answers to common SynoCell questions: is it legit, ingredients, does it work, how to take it, side effects, medicines, FDA status, price, results and refund. Type a word to filter the list.
No question matches. Try another word, or call the order desk.
SynoCell is sold with facts you can check: the Supplement Facts on the brand's product page, listed prices of $59, $147 and $234, and a 90-day money-back policy. Tracking and refund questions go to +1 (302) 200-3480. No trial has tested the formula itself, so judge it by how you feel within the 90 days.
Per 2 capsules: avocado/soybean unsaponifiables 310 mg, quercetin 310 mg, Boswellia serrata extract 200 mg, hyaluronic acid 180 mg and black pepper extract (BioPerine) 5 mg, per the brand's Supplement Facts (SynoCell, product page).
No trial has tested SynoCell itself. ASU showed a small pain benefit at a similar dose, and different Boswellia extracts showed small benefits (Cameron and Chrubasik, 2014) (Yu et al., 2020), and quercetin has no human joint trials. Exercise and weight loss remain the best-proven steps (ACR, 2026 OA guideline summary).
The serving is 2 capsules a day. Take them with a meal and a glass of water at the same time each day, and follow the directions on your bottle.
The brand does not publish side-effect data for SynoCell itself. The bigger concern is other prescriptions, since quercetin and piperine can change levels of some drugs. Ask your doctor or pharmacist first if you take blood thinners or other daily prescriptions.
Ask your doctor or pharmacist first if you take blood thinners, cyclosporine, seizure or heart medicines, or other daily prescriptions. Quercetin and piperine can change levels of some drugs (MSKCC, Quercetin) (Ziegenhagen et al., 2021).
Reliable safety data are lacking for ASU and isolated piperine in pregnancy, so skip SynoCell unless your doctor says otherwise. It is for adults 18 and older. Ask first if you have kidney disease or a soy allergy, or take blood thinners or seizure medicines.
No. FDA does not approve dietary supplements, and a registered-facility badge does not mean approval (FDA, Approval myths) (FDA, Questions and Answers on Dietary Supplements).
On October 11, 2026 the brand store listed 1 bottle at $59, 3 bottles at $147 ($49 each) and 6 bottles at $234 ($39 each), with free standard shipping in the mainland U.S.
Yes, within 90 days. Call +1 (302) 200-3480 with your order ID. On the brand store, multi-pack refunds cover unopened bottles plus one opened bottle, minus about 10% shipping and handling (SynoCell, shipping and refund policy).
The brand publishes no timeline for results. Boswellia trials ran about 90 days and a review suggests at least 4 weeks (Yu et al., 2020) (Sengupta et al., 2008), so judge it over two to three months, inside the 90-day window.
You can order SynoCell through the order buttons on this site. On October 11, 2026 the brand store listed 1 bottle at $59, 3 bottles at $147 and 6 bottles at $234, with free standard shipping in the mainland U.S. Every order comes with a 90-day money-back policy.
On October 11, 2026 the brand store listed free standard shipping in the mainland U.S. on SynoCell orders. One 60-capsule bottle lasts 30 days at 2 capsules a day.
Take 2 SynoCell capsules once a day with a meal and a full glass of water. A 60-capsule bottle covers 30 days.
Who wrote this
The SynoCell pages are written by the editorial team from the label, the brand store and linked medical sources. A named medical reviewer is shown below. This site is run by a U.S. retailer, not by the manufacturer.
Plain-language pages built from the label, the brand store and linked medical sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by an authorized U.S. retailer, not by the manufacturer. We earn money when you buy through our order links.
USA authorized SynoCell retailer
Order SynoCell through the buttons on this site. Pick a pack: take 2 capsules a day, and the 90-day money-back policy gives you three months to decide. Standard shipping in the mainland U.S. is free.